Manejo terapéutico de la hiperprolactinemia. Therapeutic management of hyperprolactinemia. Visits. J M. Cabezas Agrícolaa, J. Cabezas-Cerratoa. Num. Pages Manejo clínico de las hiperprolactinemias. Clinical management of hyperprolactinemia. Visits. Download PDF. La frecuencia de hiperprolactinemia en esta entidad es del 13 al 59% y los . Artículo. B. Farzati,G. Mazziotti,G. Cuomo,M. Ressa,F. Sorvillo,G. Amato.

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Author information Article notes Copyright and License information Disclaimer. Prevalence, clinical definition, and therapeutic strategy. GH and IGF-1 regulate somatic growth, including cardiac development and function As with other subjects related to neuroendocrinology, it should be taken into account that little high-quality evidence is available in many aspects.

CSF rhinorrhoea following treatment with dopamine agonists for massive invasive prolactinomas.

Alteraciones endocrinas en la esclerosis sistémica | Reumatología Clínica

Once physiological causes such as pregnancy, systemic disorders such as primary hypothyroidism and the use of drugs with dopamine antagonistic actions such as metochlopramide have been ruled out, the most common cause of hyperprolactinemia is a PRL-secreting pituitary adenoma or prolactinoma. Hyperprolactinemia causes decreased libido, erectile dysfunction, oligospermia and infertility and, less frequently, gynecomastia and galactorrhea.

The starting dose is 0. Anovulation, galactorrhea, hyperprolactinemia, prolactin, prolactinomas. There is no evidence that estrogen therapy increases tumor size in these patients, but prospective studies would be needed to clarify this. Galactorrhea, a typical symptom of hyperprolactinemia, occurs in less than half the cases. GHD is associated with increased body fat and central adiposity, dyslipidemia low high density lipoprotein cholesterol [HDLc], high total cholesterol, and high low density lipoprotein cholesterol [LDLc]endothelial dysfunction, and insulin resistance 1617 Figure 1.



Adapted with permission from Stowasser. Print Send to a friend Export reference Mendeley Statistics. Recurrence is correlated to the duration of treatment with dopamine agonists, PRL levels at diagnosis, and initial tumor size. The efficacy of radiotherapy should always be weighed against the complications derived from the treatment. Hypogonadism induced by hyperprolactinemia is associated with decreased mineral hiperprolacttinemia density in both sexes.

Since microprolactinomas rarely grow, 15 patients with asymptomatic microprolactinoma do not mandatorily require treatment. In our view, it is advisable to monitor the course of BMD and to consider the use of specific treatment if no recovery occurs when gonadal function is restored.

Prevalence of hyperprolactinemia with the different antipsychotic agents. Histamine giperprolactinemia a predominantly stimulatory effect due to the inhibition of the dopaminergic system. No scientific evidence is available to support the recommendation by some authors to discontinue dopamine agonists before radiotherapy is administered to improve its results.

Hormone-mediated cardiac changes should be considered when evaluating endocrine and cardiac patients. Pituitary, 12pp. J Clin Endocrinol Metab, 48pp.


J Neurosurg,pp. Whenever possible, the available evidence on each subject hiperprolactienmia been categorized based on the grades of recommendation GRADE system used by the Endocrine Society in preparing its clinical guidelines. Prolactinomas are usually classified as microprolactinomas less than 1 cm or macroprolactinomas larger than 1 cmwhich can either be confined or invasive.

From Monday to Friday from 9 a. This treatment duration raises concern for increased risks of valvulopathy, including tricuspid regurgitation, mitral regurgitation, and aortic regurgitation.


Transsphenoidal surgery for pituitary tumors in the United States, The journal fully endorses the goals of updating knowledge and facilitating the acquisition of key developments in internal medicine applied to clinical practice. J Neurochem, 97pp.

Prevalence of hyperprolactinemia with the different antipsychotic agents. Rheumatology, 38pp.

In any case, because of the duration of these treatments lifetime administration is sometimes requiredit is advisable to keep a record of the cumulative doses of dopamine agonists.

Previous article Next article. Type 1 AIT is managed with antithyroid drugs and possibly potassium perchlorate. The hemodynamic changes in hypothyroidism are the opposite of those seen in hyperthyroidism. In these cases, the first choice would be bromocriptine.